반응 #51658

반응 방정식

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

→

7-methoxy-3-methylsulfanyl-1H-indole

수율 87.5%

용매

DMSO

반응 조건

후처리

1. 1
   기타placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
2. 2
   기타The flask was placed on a steam bath
3. 3
   온도heated until the bubbling
4. 4
   온도the reaction mixture was cooled
5. 5
   기타partitioned between ether and water
6. 6
   기타The organic layer was dried
7. 7
   여과filtered
8. 8
   기타evaporated to dryness

실험 절차

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

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