반응 #51656

반응 방정식

4.1

tropenol 3,3′,4,4′-tetrafluorobenzilate

bromoethane

→

tropenol 3,3′,4,4′-tetrafluorobenzilate ethylbromide

용매

acetonitrile

dichloromethane

반응 조건

후처리

1. 1
   기타the reaction vessel is sealed
2. 2
   workup.WAITIt is left
3. 3
   workup.WAITto stand at about 20° C. for 3 weeks with the exclusion of light
4. 4
   기타The solution is evaporated to dryness
5. 5
   기타the residue is recrystallized from acetonitrile

실험 절차

2.00 g (0.0048 mol) of 4.1 is dissolved in 20 ml dichloromethane and 20 ml acetonitrile, combined with 2.59 g (0.0238 mol) of bromoethane and the reaction vessel is sealed. It is left to stand at about 20° C. for 3 weeks with the exclusion of light. The solution is evaporated to dryness and the residue is recrystallized from acetonitrile. Yield: 1.96 g of 3 (78% of theory); TLC: Rf value: 0.11 (eluant as in step II.1); melting point: 247° C.

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