반응 #516416

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4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid

sulfuric acid

methanol

→

title compound

수율 95.0%

methyl 4′-hydroxy[1,1′-biphenyl]-4-carboxylate

수율 95.0%

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후처리

1. 1
   온도at reflux temperature for 24 hours
2. 2
   여과filtered
3. 3
   세척The filter cake was washed with cold methanol (2×25 mL)
4. 4
   기타dried under reduced pressure

실험 절차

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid (5.0 g, 23.34 mmol, purchased from Aldrich Chemical Co.) and sulfuric acid (0.5 mL) in methanol (100 mL) were heated at reflux temperature for 24 hours. The mixture was allowed to cool to ambient temperature and then filtered. The filter cake was washed with cold methanol (2×25 mL) and dried under reduced pressure to provide the title compound (95% yield).

출처