반응 #51635

반응 방정식

bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde

N-cyclohexylthiourea

→

desired compound

7-[2-(cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3H)-one

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타The mixture is quenched with 10% dimethylamine in ethanol
2. 2
   기타the solvent is removed
3. 3
   기타The crude is purified by chromatography on silica gel

실험 절차

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

출처