반응 #51634

반응 방정식

bromo(4-nitrophenyl)acetaldehyde

potassium thiocyanate

cyclohexylamine

→

desired compound

N-cyclohexyl-5-(4-nitrophenyl)-1,3-thiazol-2-amine

용매

methanol

반응 조건

후처리

1. 1
   온도the mixture is heated
2. 2
   온도under reflux until completion of the reaction (5-12 hours)
3. 3
   여과is filtered off
4. 4
   세척washed with water
5. 5
   기타The crude material is purified by usual silica gel chromatography

실험 절차

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

출처