반응 #51575

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3-bromo-5-chloro-2-cyanopyridine

tert-butyl (7bR,11aS)6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate

→

title compound

(7bR,11aS)-N-(5-Chloro-2-cyano-3-pyridinyl)1,2,7b,8,9,10,11,11a-octahydro-4H-[1,41 oxazepino[6,5,4-hi]pyrido[4,3-b]indole-6-amine, bis hydrochloride salt

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실험 절차

Following the procedures described in Example 176 and using 3-bromo-5-chloro-2-cyanopyridine, tert-butyl (7bR,11aS)6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from Example 56, Part B was converted into the title compound of Example 177. ESI MS m/z 382.3/384.3 [C20H20CIN5O+H]+.

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