반응 #51475

반응 방정식

2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methyl-4-pyrimidinyl]amino]acetic acid

carbonyldiimidazole

diethylamine

→

2-[(2-cyanoethyl)[2-(1H-imidazol-1yl)-6-methyl-4-pyrimidinyl]amino]-N,N-diethylacetamide

수율 50.3%

용매

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring for 18 hours
2. 2
   기타the reaction was partitioned with ethyl acetate and water
3. 3
   기타The organic layer was separated
4. 4
   건조dried (Na2SO4)
5. 5
   기타the solvent was removed in vacuo

실험 절차

To 2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methyl-4-pyrimidinyl]amino]acetic acid (1.53 g, 5.3 mmol) slurried in DMF (25 mL) was added carbonyldiimidazole (0.87 g, 5.4 mmol). After stirring for 2 hours, diethylamine (1.0 mL, 9.7 mmol) (a compound of formula (Y4)) was added. After stirring for 18 hours, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, dried (Na2SO4), and the solvent was removed in vacuo to give 0.91 g of 2-[(2-cyanoethyl)[2-(1H-imidazol-1yl)-6-methyl-4-pyrimidinyl]amino]-N,N-diethylacetamide (a compound of formula (Yc3)).

출처