반응 #5146

반응 방정식

methacryloyl chloride

2-bromo-4-2-hydroxyethoxymethylthiophene

pyridine

acetonitrile

water

→

2-bromo-4-thienyl-methoxyethyl methacrylate

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring the mixture for one hour
2. 2
   추출The ethyl acetate layer was extracted
3. 3
   농축concentrated
4. 4
   기타purified by column chromatography

실험 절차

While stirring a mixture of 0.1 mol of 2-bromo-4-2-hydroxyethoxymethylthiophene, 0.1 mol of pyridine, and 100 ml of acetonitrile at a temperature of lower than 10° C., 0.1 mol of methacryloyl chloride was added dropwise to the mixture over a period of 30 minutes. After stirring the mixture for one hour, 200 ml of ethyl acetate and 200 ml of water were added to the mixture. The ethyl acetate layer was extracted, concentrated, and purified by column chromatography to provide 22.1 g of 2-bromo-4-thienyl-methoxyethyl methacrylate (5-A).

출처