반응 #51432

반응 방정식

6-Nitro-1H-indole-2-carboxylic acid methyl ester

N1,N1-dimethyl-ethane-1,2-diamine

→

yellow solid

수율 84.0%

6-Nitro-1H-indole-2-carboxylic acid (2-dimethylamino-ethyl)-amide

수율 84.0%

반응 조건

후처리

1. 1
   기타was evaporated
2. 2
   기타The oily residue was triturated with n-hexane

실험 절차

500 mg (2.27 mmole) 6-Nitro-1H-indole-2-carboxylic acid methyl ester was dissolved in 4 mL neat N1,N1-dimethyl-ethane-1,2-diamine, was kept at 55° C. overnight and was evaporated. The oily residue was triturated with n-hexane to give 528 mg (84%) yellow solid which was no further purified. MS: 277.13 (calcd for M+H+:277.13)

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