반응 #513424

반응 방정식

(2-Chloro-pyridin-4-yl)-methanol

sodium methoxide

→

(2-Methoxy-pyridin-4-yl)-methanol

수율 60.0%

반응 조건

후처리

1. 1
   기타the mixture was evaporated in vacuo
2. 2
   기타the residue was purified by silica gel column chromatography (eluent, EA:hexane (1:1))

실험 절차

(2-Chloro-pyridin-4-yl)-methanol (2.82 g, 19.67 mmol) was refluxed with 25 wt. % sodium methoxide (25 ml) solution for 24 hr. After cooling to room temperature, the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA:hexane (1:1)) to afford 1.8 g (60%) of (2-Methoxy-pyridin-4-yl)-methanol as a pale brown oil. 1H NMR (200 MHz, CDCl3) δ 2.16 (3H, s), 2.21 (3H, s), 5.13 (2H, s), 6.99 (1H, d, J=5.6 Hz), 8.11 (1H, br. s), 8.12 (1H, s), 8.23 (1H, d, J=5.6 Hz).

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