반응 #51338
ord-67ada832f8c24662847c20f8da7631de
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure
실험 절차
A mixture of 35.64 g (0.4 mol) of (D,L)-alanine (Aldrich) (or L-alanine (Aldrich)); 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of isobutanol was refluxed for 1.5 hours and the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure to give (D,L)-alanine iso-butyl ester hydrochloride (or L-alanine iso-butyl ester hydrochloride), which was pure enough to be used for further transformations.