반응 #51289

반응 방정식

4-Phenyl-furazan-3-ylamine

ethyl pyruvate

→

title compound

N-(Phenyl-furazan-3-yl)-D,L-alanine

용매

ethanol

반응 조건

후처리

1. 1
   기타at 150° C.
2. 2
   기타for 8 hours
3. 3
   여과The reaction mixture was then filtered through Celite
4. 4
   농축the filtrate was concentrated under reduced pressure
5. 5
   기타The residue was purified by silica gel chromatography

실험 절차

4-Phenyl-furazan-3-ylamine (Maybridge) and ethyl pyruvate (Aldrich) were dissolved in dry ethanol. Platinum on sulfide carbon (5%) was added and the resulting mixture was hydrogenated (1000 psi, H2) at 150° C. for 8 hours. The reaction mixture was then filtered through Celite and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography using CHCl3 as the eluent to provide the title compound as its ethyl ester. The ethyl ester was then hydrolyzed using General Procedure II-A, Method B (LiOH/H2O/dioxane) to provide the title compound.

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