반응 #51258

반응 방정식

product

8-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

NMP

→

title compound

수율 90.5%

8-amino-1-{4-[(aminothio)peroxy]phenyl}-1H-benzo[g]indazole-3-carboxamide

수율 90.5%

용매

cumene

반응 조건

후처리

1. 1
   온도at reflux for 16 h
2. 2
   여과The mixture was then filtered
3. 3
   농축concentrated
4. 4
   workup.ADDITIONThe residue was diluted with methanol (10 mL)
5. 5
   workup.ADDITIONadded to water, after 1 h the resulting precipitate
6. 6
   여과was collected by filtration
7. 7
   기타dried

실험 절차

The product of Example 4b (1 g) and 5% Pd/C (300 mg) suspended in cumene (50 mL) and NMP (5 mL) was heated at reflux for 16 h. The mixture was then filtered and concentrated. The residue was diluted with methanol (10 mL) and added to water, after 1 h the resulting precipitate was collected by filtration and dried to yield the title compound (0.9 g).

출처