반응 #51242

반응 방정식

sodium bicarbonate

ethyl glycolate

sodium hydride

1,4-dibromobutane

→

(4-Bromo-butoxy)-acetic Acid Ethyl Ester

용매

DMF

반응 조건

후처리

1. 1
   건조the organic layer was dried over anhydrous sodium sulfate
2. 2
   농축concentrated
3. 3
   기타the residue was purified by chromatography
4. 4
   기타to afford a colorless oil

실험 절차

To a solution of sodium hydride in 40 mL DMF stirred at 0° C. was slowly added ethyl glycolate (5 g, 48 mmol). After 1 hour, 1,4-dibromobutane (8.6 mL, 72 mmol) was added, and the mixture was stirred for an additional 2 hours. The reaction was allowed to warm to room temperature for an additional 3 hours. A sodium bicarbonate solution was added, and the organic layer was dried over anhydrous sodium sulfate, concentrated and the residue was purified by chromatography to afford a colorless oil.

출처