반응 #51229

반응 방정식

sodium hydroxide

N-benzyloxycarbonyl-trans-4-[(6-nitro-1-indolinyl)carbonyl]cyclohexylamine

→

N-benzyloxycarbonyl-trans-4-[(6-amino-1-indolinyl)carbonyl]cyclohexylamine

수율 83.5%

용매

chloroform

반응 조건

후처리

1. 1
   기타obtained in the same manner as in Reference Example 13-1 before deprotection), and the mixture
2. 2
   온도was refluxed under argon atmosphere for 4.5 hours
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   기타the insolubles were removed by filtration
5. 5
   농축The filtrate was concentrated under reduced pressure
6. 6
   기타the resulting residue was purified by silica gel column chromatography (solvent: chloroform-ethyl acetate (2:1))

실험 절차

17.33 g of stannous chloride was added to a hydrated ethanol (120 ml of ethanol+1.2 ml of water) suspension containing 6.08 g of N-benzyloxycarbonyl-trans-4-[(6-nitro-1-indolinyl)carbonyl]cyclohexylamine (the compound obtained in the same manner as in Reference Example 13-1 before deprotection), and the mixture was refluxed under argon atmosphere for 4.5 hours. An aqueous 10% sodium hydroxide solution was added to the reaction mixture to adjust pH of the mixture to pH 9 to 10, the mixture was diluted with 300 ml of chloroform and dried over anhydrous magnesium sulfate, and then, the insolubles were removed by filtration. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (solvent: chloroform-ethyl acetate (2:1)) to obtain 4.72 g of N-benzyloxycarbonyl-trans-4-[(6-amino-1-indolinyl)carbonyl]cyclohexylamine.

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