반응 #51228
ord-3ec4e80e1edf430a8ee4eedd99c59306
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타Manganese dioxide was removed by filtration through Celite
- 2기타the solvent was removed under reduced pressure
- 3여과the crystals were collected by filtration
실험 절차
20 g of manganese dioxide was added to 120 ml of a chloroform solution containing 4.0 g of N-benzyloxycarbonyl-trans-4-[(5-hydroxymethyl-2-isoindolinyl)carbonyl]cyclohexylamine, and the mixture was stirred at room temperature for 4 hours. Manganese dioxide was removed by filtration through Celite and the solvent was removed under reduced pressure. The residue was suspended in hexane-ethyl acetate and the crystals were collected by filtration to obtain N-benzyloxycarbonyl-trans-4-[(5-formyl-2-isoindolinyl)carbonyl]cyclohexylamine.