반응 #5121

반응 방정식

3,4-methylenedioxycinnamic acid

water

hydrogen

→

3-(3,4-methylenedioxyphenyl) propanoic acid

수율 97.0%

용매

NaOH

반응 조건

후처리

1. 1
   여과filtered through a Celite layer
2. 2
   온도to be cooled
3. 3
   여과filtered
4. 4
   기타to give solids
5. 5
   세척The obtained solids were washed twice with 100 ml of cold water
6. 6
   기타dried

실험 절차

To a solution of 10.0 g of 3,4-methylenedioxycinnamic acid dissolved in 130 ml of 10% NaOH and 80 ml of distilled water was added 1.0 g of 5% Pd-C. This mixture was reacted at 40 psi until the consumption of hydrogen gas was ceased and then filtered through a Celite layer. The filtrate was acidified with concentrated hydrochloric acid, allowed to be cooled and filtered to give solids. The obtained solids were washed twice with 100 ml of cold water and dried to provide 9.8 g(yield 97%) of 3-(3,4-methylenedioxyphenyl) propanoic acid, having the characteristics of: NMR(CDCl3, 200 MHz) δ2.62(t, J=7 Hz, 2H, CH2), 2.88(t, J=7 Hz, 2H, CH2N), 5.93(s, 2H, CH2O2), 6.63-6.76(s, 3H, ArH).

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