반응 #51163

반응 방정식

2-chloro-6-methoxy-3-nitropyridine

sodium thiomethoxide

→

6-methoxy-2-methylthio-3-nitropyridine

수율 60.5%

용매

methanol

methanol

반응 조건

후처리

1. 1
   온도while being cooled with ice
2. 2
   여과the precipitated crystal was filtered

실험 절차

A methanol (100 ml) solution of 2-chloro-6-methoxy-3-nitropyridine (2.0 g, 10.4 mmol) was added dropwise to a methanol (20 ml) solution of sodium thiomethoxide (805 mg, 10.9 mmol) while being cooled with ice, and the temperature thereof was raised to the room temperature and the mixed solution was stirred for 17 hours and the precipitated crystal was filtered to obtain 1.26 g (yield 59%) of 6-methoxy-2-methylthio-3-nitropyridine as a yellow powdery crystal.

출처