반응 #51047

반응 방정식

3-bromopropanol

N-methylpiperazine

potassium carbonate

→

1-(3-hydroxypropyl)-4-methylpiperazine

용매

ethanol

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도to reflux for 20 hours
3. 3
   여과filtered
4. 4
   기타The filtrate was evaporated
5. 5
   기타the residue was triturated under diethyl ether
6. 6
   여과The resultant mixture was filtered
7. 7
   기타the filtrate was evaporated
8. 8
   workup.DISTILLATIONThe residue was purified by distillation at about 60-70° C. under about 0.2 mm Hg

실험 절차

A mixture of 3-bromopropanol (20 ml), N-methylpiperazine (29 ml), potassium carbonate (83 g) and ethanol (200 ml)was stirred and heated to reflux for 20 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated and the residue was triturated under diethyl ether. The resultant mixture was filtered and the filtrate was evaporated. The residue was purified by distillation at about 60-70° C. under about 0.2 mm Hg to give 1-(3-hydroxypropyl)-4-methylpiperazine (17 g); NMR Spectrum: (CDCl3) 1.72 (m, 2H), 2.3 (s, 3H), 2.2-2.8 (m, 8H), 2.6 (t, 2H), 3.8 (t, 2H), 5.3 (br s, 1H).

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