반응 #51028

반응 방정식

3-methoxy-6-(N-benzylindole-5-sulfonyl)-2H-pyridazine

HCl

→

6-(N-Benzylindole-5-sulfonyl)-2H-pyridazin-3-one

용매

dioxane

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   기타evaporated to dryness
3. 3
   workup.ADDITIONWater (10 mL) was added to the residue
4. 4
   기타the resulting solid, 6-(N-benzylindole-5-sulfonyl)-2H-pyridazin-3-one, was collected (55%, 102 mg)

실험 절차

A mixture of 3-methoxy-6-(N-benzylindole-5-sulfonyl)-2H-pyridazine (0.64 mmol, 245 mg), conc. HCl (0.5 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue and the resulting solid, 6-(N-benzylindole-5-sulfonyl)-2H-pyridazin-3-one, was collected (55%, 102 mg).

출처