반응 #509174

반응 방정식

tert-butyl (1S,4S)-5-(2,3-dichlorobenzoyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

methanol

hydrochloride

→

title compound

(1S,4S)-2-(2,3-dichlorobenzoyl)-2,5-diazabicyclo[2.2.1]heptane

용매

1,4-dioxane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   여과The precipitate was filtered
3. 3
   기타dried

실험 절차

To a mixture of 5.5 g of tert-butyl (1S,4S)-5-(2,3-dichlorobenzoyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate and 10 ml of methanol was added hydrochloride in 1,4-dioxane solution (4 mol/l, 20 ml) followed by stirring for 1.5 hour at room temperature. The reaction mixture was concentrated in vacuo and then the resulting residue was suspended with diethylether. The precipitate was filtered and dried to give a crystal of the title compound.

출처