반응 #50879

반응 방정식

isophtalaldehyde

NaBH4

→

title compound

3-hydroxymethylbenzaldehyde

용매

ethanol

반응 조건

후처리

1. 1
   기타until about 50% reaction by TLC
2. 2
   기타The reaction mixture was quenched with 25% ammonium acetate
3. 3
   추출extracted with ethyl acetate, which
4. 4
   세척was washed with brine (2×)
5. 5
   건조dried over sodium sulfate
6. 6
   여과filtered
7. 7
   기타evaporated to dryness
8. 8
   기타Purification of the residue by flash chromatography

실험 절차

To a solution of isophtalaldehyde (8 g) in ethanol (80 mL) at room temperature was added NaBH4 portion wise, until about 50% reaction by TLC. The reaction mixture was quenched with 25% ammonium acetate, extracted with ethyl acetate, which was washed with brine (2×), dried over sodium sulfate, filtered and evaporated to dryness. Purification of the residue by flash chromatography using 50% ether in hexane afforded the pure title compound.

출처