반응 #50863

반응 방정식

ether

2-bromomethyl-7-chloroquinoline

phenol

dimethyl 5-(3-hydroxyphenyl)-4,6-dithianonanedioate

K2CO3

→

title compound

dimethyl 5-(3-((7-chloroquinolin-2-yl-methyl)oxy)phenyl)-4,6-dithianonanedioate

용매

methyl ethyl ketone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도The reaction mixture was cooled
3. 3
   여과The suspension was filtered
4. 4
   기타evaporated

실험 절차

A mixture of 2-bromomethyl-7-chloroquinoline (2.5 g) (Step 2), phenol (Step 1) (3.4 g) and K2CO3 (3 g) was heated at reflux for 4 hours in methyl ethyl ketone (100 ml). The reaction mixture was cooled and ether (100 ml) was added. The suspension was filtered and evaporated. Flash chromatography of the residue using 30% ethyl acetate in hexane afforded the title compound.

출처