반응 #50862

반응 방정식

N-bromosuccinimide

7-chloroquinaldine

dibenzoylperoxide

→

title compound

2-bromomethyl-7-chloroquinoline

용매

CCl4

반응 조건

후처리

1. 1
   온도The suspension was cooled
2. 2
   세척The plug of silica gel was washed with 30% ether in hexane
3. 3
   기타the filtrate was evaporated

실험 절차

A stirred suspension of N-bromosuccinimide (9.0 g), 7-chloroquinaldine (9.0 g), dibenzoylperoxide (0.5 g ) in CCl4 (200 ml) at 90° was illuminated with a 225W sunlamp for 6 hours. The suspension was cooled and passed through a plug of silica gel. The plug of silica gel was washed with 30% ether in hexane and the filtrate was evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.

출처