반응 #50859

반응 방정식

isophthalaldehyde

trimethylsilylchloride

methyl 3 -mercaptopropanoate

→

title compound

dimethyl 5-(3-formylphenyl)-4,6-dithianonanedioate

용매

CHCl3

반응 조건

후처리

1. 1
   기타quenched with aqueous NH4OAc (25%)
2. 2
   추출extracted with ethylacetate

실험 절차

To a solution of isophthalaldehyde (5.4 g) in CHCl3 (50 ml) and methyl 3 -mercaptopropanoate (9.2 ml) was added dropwise trimethylsilylchloride (6.5 ml). The reaction mixture was stirred 1 hour at room temperature, quenched with aqueous NH4OAc (25%), and extracted with ethylacetate. Flash chromatography of the residue using 1:1 ethylacetate hexane afforded the title compound.

출처