반응 #50849

반응 방정식

1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone

→

1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone

용매

thionyl chloride

반응 조건

후처리

1. 1
   추출The aqueous phase is extracted with ether (3×20 ml)
2. 2
   기타The organic phase is dried
3. 3
   기타evaporated

실험 절차

A solution of 0.5 g of 1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone in 20 ml of thionyl chloride is refluxed for 3 h and poured into 100 ml of ice-water. The aqueous phase is extracted with ether (3×20 ml), adjusted to pH=10 and reextracted with methylene chloride. The organic phase is dried and evaporated to yield 1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone.

출처