반응 #508486

반응 방정식

N-Mesylpiperazine

dimethyl sulfoxide

5-[8-chloro-9-(cyclopropylmethyl)-6-morpholin-4-yl-9H-purin-2-yl]-N-methylpyrimidin-2-amine

N-mesylpiperazine

→

5-{9-(Cyclopropylmethyl)-8-[4-(methylsulfonyl)piperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}-N-methylpyrimidin-2-amine

용매

dichloromethane methanol

반응 조건

후처리

1. 1
   workup.STIRRINGthe resulting mixture was further stirred for 5.5 hours
2. 2
   workup.WAITleft
3. 3
   온도to cool
4. 4
   세척the resulting mixture was washed with saturated aqueous sodium hydrogen carbonate solution

실험 절차

A dimethyl sulfoxide solution (1.0 ml) of 5-[8-chloro-9-(cyclopropylmethyl)-6-morpholin-4-yl-9H-purin-2-yl]-N-methylpyrimidin-2-amine (140.5 mg, 0.29 mmol) and N-mesylpiperazine (190.2 mg, 1.16 mmol) was heated at 140° C. and stirred for 3 hours. N-Mesylpiperazine (190.2 mg, 1.16 mmol) was added, the resulting mixture was further stirred for 5.5 hours and left standing to cool followed by the addition of dichloromethane-methanol (10:1), and the resulting mixture was washed with saturated aqueous sodium hydrogen carbonate solution.

출처