반응 #50848

반응 방정식

ammonium chloride

n-butyllithium

N-tert-butyl-p-bromobenzamide

4-(1-trityl-4-imidazolyl)-butanoic acid

→

1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The organic layer is separated
2. 2
   건조dried over sodium sulfate
3. 3
   기타evaporated

실험 절차

6.95 g of N-tert-butyl-p-bromobenzamide is dissolved in 175 ml of tetrahydrofuran at -70° under nitrogen and 20.1 ml of n-butyllithium (2.7M) is added dropwise. After 30 min, a solution of 5.35 g of 4-(1-trityl-4-imidazolyl)-butanoic acid in 10 ml of tetrahydrofuran is added slowly. The reaction mixture is allowed to warm slowly to room temperature and 20 ml of an aqueous ammonium chloride solution is added. The organic layer is separated, dried over sodium sulfate and evaporated to yield 1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone

출처