반응 #50846

반응 방정식

5-(p-cyanophenyl)-3-ethoxycarbonyl-imidazo[1,5-a]pyridine

→

5-(p-cyanophenyl)-3-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

용매

ethanol

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타evaporated to dryness
3. 3
   기타The resulting oil is partitioned between water and ethyl acetate
4. 4
   기타The organic phase is separated
5. 5
   건조dried over sodium sulfate
6. 6
   기타evaporated
7. 7
   기타The residue is chromatographed on 40 g of silica gel with ethyl acetate

실험 절차

A solution of 1.1 g of 5-(p-cyanophenyl)-3-ethoxycarbonyl-imidazo[1,5-a]pyridine in 30 ml of ethanol is hydrogenated with 0.1 g of 10% Pd on charcoal at 1 bar for 2 h, filtered and evaporated to dryness. The resulting oil is partitioned between water and ethyl acetate. The organic phase is separated, dried over sodium sulfate and evaporated. The residue is chromatographed on 40 g of silica gel with ethyl acetate to yield 5-(p-cyanophenyl)-3-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine.

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