반응 #50833

반응 방정식

hydrochloric acid

5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

sodium hydroxide

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

용매

methanol

반응 조건

후처리

1. 1
   온도The reaction mixture is refluxed for 1 h
2. 2
   온도cooled
3. 3
   기타evaporated
4. 4
   기타The residue is partitioned between water and ethyl acetate
5. 5
   기타The organic layer is separated
6. 6
   건조dried over sodium sulfate
7. 7
   기타evaporated

실험 절차

A solution of 1.65 g of 5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 10 ml of methanol containing 0.2 g of sodium hydroxide is stirred for 3 h at room temperature and 5 ml of 1N hydrochloric acid is added. The reaction mixture is refluxed for 1 h, cooled and evaporated. The residue is partitioned between water and ethyl acetate. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound.

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