반응 #508233

반응 방정식

3-({N-[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}-4 hydroxyphenyl)-2-cyanoacrylic acid methyl ester

sodium hydroxide

hydrochloric acid

→

title compound

수율 30.4%

3-({N-[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}-4-hydroxyphenyl)-2-cyanoacrylic acid

수율 30.4%

용매

ethanol

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척After the organic layer was washed with brine
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   기타the residue obtained by evaporation under reduced pressure
5. 5
   기타was recrystallized (ethyl acetate)

실험 절차

3-({N-[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}-4 hydroxyphenyl)-2-cyanoacrylic acid methyl ester (50 mg, 0.11 mmol) was dissolved in ethanol (5 mL). 2 N sodium hydroxide (0.11 ml, 0.22 mmol) was added, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate. After the organic layer was washed with brine, dried over anhydrous magnesium sulfate, the residue obtained by evaporation under reduced pressure was recrystallized (ethyl acetate) to give the title compound (13.5 mg, 30.4%) as a light yellow solid.

출처