반응 #50816

반응 방정식

sodium bicarbonate

5-(p-carboxyphenyl)imidazo[1,5-a]pyridine

oxalyl chloride

tert-butylamine

→

title compound

5-(p-tert-Butylaminocarbonylphenyl)imidazo[1,5-a]pyridine

용매

methylene chloride

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGStirring
2. 2
   기타The organic layer is separated
3. 3
   건조dried over sodium sulfate
4. 4
   기타evaporated

실험 절차

To a slurry of 0.4 g of 5-(p-carboxyphenyl)imidazo[1,5-a]pyridine in 40 ml of methylene chloride under nitrogen at room temperature, is added 30 μl of N,N-dimethylformamide followed by 0.16 ml of oxalyl chloride. The reaction mixture is stirred until gas evolution is complete and 0.46 ml of tert-butylamine is added dropwise. Stirring is discontinued after 90 min and 10 ml of saturated sodium bicarbonate solution is added. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound, m.p. 128°-131°.

출처