반응 #50789

반응 방정식

2-carboxy-indan

methanol

→

2-carbomethoxy-indan

반응 조건

후처리

1. 1
   농축Saturate with hydrochloride gas
2. 2
   기타then evaporate the solvent in vacuo
3. 3
   기타Purify by silica gel chromatography (2:1 methylene chloride/hexane)

실험 절차

Dissolve 2-carboxy-indan (2.5 g, 15.4 mmol) in methanol and cool to 0° C. Saturate with hydrochloride gas then add 2,2-dimethoxypropane (2-3 mL). Stir overnight then evaporate the solvent in vacuo. Purify by silica gel chromatography (2:1 methylene chloride/hexane) to give 2-carbomethoxy-indan as a water white oil. (2.04 g, 75%).

출처