반응 #50778

반응 방정식

5,7-di-tert-butyl-3-[4-(2-hydroxyethoxy)phenyl]ben-zofuran-2-one

5,7-di-tert-butyl-3-[4-(2-hydroxyethoxy)phenyl]-benzofuran-2-one

compound ( 105 )

5,7-di-tert-butyl-3-[4-(2-hydroxyethoxy)phenyl]-benzofuran-2-one

stearoyl chloride

→

5,7-di-tert-butyl-3-[4-(2-stearoyloxyethoxy)phenyl]benzofuran-2-one

수율 89.0%

용매

toluene

반응 조건

후처리

1. 1
   온도is refluxed for 4 hours
2. 2
   농축The reaction mixture is then concentrated on a vacuum rotary evaporator
3. 3
   기타the residue is recrystallized from methanol

실험 절차

A suspension of 11.4 g (30 mmol) of 5,7-di-tert-butyl-3-[4-(2-hydroxyethoxy)phenyl]ben-zofuran-2-one (compound (105), Example 3) and 9.4 g (31 mmol) of stearoyl chloride in 60 ml of toluene is refluxed for 4 hours. The reaction mixture is then concentrated on a vacuum rotary evaporator, and the residue is recrystallized from methanol to give 17.3 g (89%) of 5,7-di-tert-butyl-3-[4-(2-stearoyloxyethoxy)phenyl]benzofuran-2-one, m.p. 54°-60° C. (compound (107), Table 1).

출처