반응 #50775

반응 방정식

4-(2-hydroxyethoxy)mandelic acid

compound ( 201 )

4-(2-hydroxyethoxy)mandelic acid

p-cresol

→

3-[4-(2-hydroxyethoxy)phenyl]-5-methylbenzofuran-2-one

수율 58.0%

용매

water

반응 조건

후처리

1. 1
   기타formed
2. 2
   기타distils off
3. 3
   workup.DISTILLATIONExcess p-cresol is then distilled off in a vacuum rotary evaporator

실험 절차

A suspension of 8.5 g (40.0 mmol) of 4-(2-hydroxyethoxy)mandelic acid (compound (201), Example 10, Table 2) and 12.0 g (110 mmol) of p-cresol is maintained at 180° C. under a nitrogen atmosphere for 75 minutes, during which the water formed distils off. Excess p-cresol is then distilled off in a vacuum rotary evaporator. Chromatography of the residue on silica gel using the eluent system 9:1 dichloromethane/ethyl acetate gives 6.6 g (58%) of 3-[4-(2-hydroxyethoxy)phenyl]-5-methylbenzofuran-2-one, a yellowish resin (compound (119), Table 1).

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