반응 #50759

반응 방정식

2,5-Dimethoxytetrahydrofuran

benzenesulphinic acid

calcium chloride

→

2-benzenesulphonyl-5-methoxytetrahydro-furan

수율 55.0%

용매

DCM

반응 조건

후처리

1. 1
   workup.ADDITIONcontaining
2. 2
   세척the solution was washed with water (2×50 ml)
3. 3
   건조dried over anhydrous sodium sulphate
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   기타The product was crystalised (diethyl ether/hexane)

실험 절차

2,5-Dimethoxytetrahydrofuran (17.1 ml, 0.13M) was added dropwise to a stirred solution of benzenesulphinic acid (17.0 g, 0.12M) in dry DCM (100 ml) containing a suspension of powdered calcium chloride (1.0 g) at room temperature under argon. After 4 h, the solution was washed with water (2×50 ml), dried over anhydrous sodium sulphate, filtered and evaporated. The product was crystalised (diethyl ether/hexane) to give 2-benzenesulphonyl-5-methoxytetrahydro-furan as a white crystalline solid (15.9 g, 55%).

출처