반응 #507288

반응 방정식

D-serine

trityl chloride

trimethylsilyl chloride

→

titled product

N-trityl-D-serine

용매

dichloromethane

methanol

dichloromethane

triethyl amine

dichloromethane

methanol

Triethylamine

반응 조건

후처리

1. 1
   기타to form a suspension
2. 2
   온도it was cooled to ambient temperature
3. 3
   온도The mixture was refluxed for 45 minutes at 35-40° C.
4. 4
   온도cooled to 0° C
5. 5
   기타to reach at room temperature
6. 6
   workup.ADDITIONwas added at ambient temperature in 10-15 minutes
7. 7
   기타the solvent was recovered under vacuum at 40-45° C
8. 8
   기타The crude product obtained
9. 9
   세척was washed with water (750 ml)
10. 10
    여과filtered
11. 11
    세척The filtered product was further washed with 5% citric acid solution (750 ml)
12. 12
    여과filtered
13. 13
    기타The solid product obtained
14. 14
    기타was partitioned between water (750 ml) and hexanes (200 ml)
15. 15
    여과filtered
16. 16
    세척The filtered solid was washed with hexanes (200 ml)
17. 17
    기타dried

실험 절차

To dichloromethane (500 ml), D-serine (50 g) was added at ambient temperature under nitrogen atmosphere to form a suspension and then trimethylsilyl chloride (180.91 g) was added to the suspension in 10-15 minutes at ambient temperature. The reaction mixture was refluxed at 35-40° C. for 20 minutes and then it was cooled to ambient temperature. To the reaction mixture, a solution of triethyl amine (168.50 g) in dichloromethane (50 ml) was added in 30-45 minutes at 25-30° C. The mixture was refluxed for 45 minutes at 35-40° C. and then cooled to 0° C. To this mixture, a solution of anhydrous methanol (22.83 g) in dichloromethane (50 ml) was added at 0° C. and the mixture was allowed to reach at room temperature. Triethylamine (48.14 g) was slowly added to it at 25-30° C. and then trityl chloride (132.63 g) was added in 3 lots to the mixture at an interval of 10 minutes. The reaction mixture was then stirred for 3 hours under nitrogen at ambient temperature. After completion of the reaction, methanol (76.12 g) was added at ambient temperature in 10-15 minutes and the solvent was recovered under vacuum at 40-45° C. The crude product obtained was washed with water (750 ml) and filtered. The filtered product was further washed with 5% citric acid solution (750 ml) and filtered. The solid product obtained was partitioned between water (750 ml) and hexanes (200 ml) and then filtered. The filtered solid was washed with hexanes (200 ml) and dried to obtain the titled product. Yield=135 gm.

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