반응 #50713
ord-887929dd97434fdeb38adfb0c5a6fa52
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타the dichloromethane separated
- 2세척washed with water
- 3건조dried over anhydrous magnesium sulphate
- 4기타evaporated
- 5기타to give an oil, which
- 6기타was chromatographed over flash silica
- 7세척eluting with chloroform
실험 절차
A 1M solution of boron tribromide in dichloromethane (5 ml, 5 mmol) was added to an ice water cooled solution of 8-(4-methoxyphenyl)octylbromide (1.5 g, 5 mmol) in dichloromethane (10 ml). After 4 hours at room temperature, water was added and the dichloromethane separated, washed with water, dried over anhydrous magnesium sulphate, and evaporated to give an oil, which was chromatographed over flash silica, eluting with chloroform, followed by 2% methanol in chloroform to give 8-(4-hydroxyphenyl)octylbromide as an oil (MS: M+ =284).