반응 #5070

반응 방정식

Potassium fluoride

Methyl 3-iodobenzoate

vinyl tributyltin

→

Methyl 3-ethylbenzoate

용매

water

toluene

ethyl acetate

반응 조건

후처리

1. 1
   온도The solution was heated
2. 2
   온도at reflux
3. 3
   workup.STIRRINGto stir under N2 for 15 minutes
4. 4
   세척washed with water
5. 5
   추출The organic extract
6. 6
   건조was dried (MgSO4)
7. 7
   기타evaporated in vacuo

실험 절차

Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.

출처