반응 #50695

반응 방정식

sodium

Diethyl malonate

sodium ethoxide

Isoamyl bromide

→

Sodium ethoxide

diethyl isoamylmalonate

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   온도the reaction mixture was heated
2. 2
   온도under reflux overnight
3. 3
   workup.DISTILLATIONAfter the usual work-up, the resulting crude product was distilled under reduced pressure

실험 절차

Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield: 71.7 g (78%).

출처