반응 #50680

반응 방정식

2-(2-acetyl-1H-pyrrol-1-yl)-1H-isoindole-1,3(2H)dione

methylamine

water

→

product

수율 93.2%

1-(1-Amino-1H-pyrrol-2-yl)ethanone

수율 93.2%

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출was extracted 4 times with EtOAc
2. 2
   세척The combined organics were washed once with water and brine
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   농축concentrated
6. 6
   기타to give the crude product
7. 7
   기타Purification via flash column chromatography (silica gel, 30% EtOAc/hexane)

실험 절차

To a suspension of 2-(2-acetyl-1H-pyrrol-1-yl)-1H-isoindole-1,3(2H)dione (8.53 g) in dimethylformamide (25 ml) was added 33 ml of 40% methylamine solution. After 2.5 hours, the reaction mixture was poured into water (300 ml) and was extracted 4 times with EtOAc. The combined organics were washed once with water and brine, dried (MgSO4), filtered and concentrated to give the crude product. Purification via flash column chromatography (silica gel, 30% EtOAc/hexane) afforded 3.88 g of the product as an oil.

출처