반응 #50645

반응 방정식

4-chloro-3-trifluoromethylcinnamonitrile

hydroxylamine hydrochloride

sodium carbonate

→

(E)-4-chloro-3-trifluoromethylcinnamamide oxime

수율 40.1%

용매

water

water

ethanol

반응 조건

후처리

1. 1
   온도The mixture is heated
2. 2
   온도at reflux temperature until the reaction
3. 3
   기타(24 hours)
4. 4
   여과is filtered off with suction
5. 5
   세척washed with a little water
6. 6
   기타dried

실험 절차

12.1 g (0.05 mol) of 4-chloro-3-trifluoromethylcinnamonitrile are added to a solution consisting of 7.2 g (0.10 mol) of hydroxylamine hydrochloride and 7.3 g (0.10 mol) of sodium carbonate in 100 ml of water and 100 ml of ethanol. The mixture is heated at reflux temperature until the reaction is complete (24 hours) and the whole batch is subsequently stirred into 250 ml of water. The solid material which separates off during this process is filtered off with suction, washed with a little water and dried. 5.3 g (39.3% of theory) of (E)-4-chloro-3-trifluoromethylcinnamamide oxime are obtained.

출처