반응 #50634

반응 방정식

Fumarate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(2-fluorophenyl)piperazine

ethanol

→

8-{3-[4-(2-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

수율 59.0%

용매

water

반응 조건

후처리

1. 1
   기타Method B (50 h at 60° C.)
2. 2
   기타being 205°-210° C.

실험 절차

Method B (50 h at 60° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-fluorophenyl)piperazine; yield 59%; fusion point 148°-150° C. (from ethanol). Fumarate (×H2O): method E; yield 78%; the fusion point being 205°-210° C. (from water).

출처