반응 #5062

반응 방정식

sodium hydroxide

lithium aluminum hydride

compound

(4-Naphth-1-ylpiperid-1-yl)acetonitrile hydrochloride

water

water

→

1-(2-Aminoeth-1-y1)-4-naphth-1-ylpiperidine

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   여과Filtration through celite
2. 2
   기타followed by evaporation of the solvent
3. 3
   기타yields an oily product which

실험 절차

1.75 g of lithium aluminum hydride are added in fractions under a stream of nitrogen to a solution of 4.4 g of the compound from Example 4 in 150 ml of tetrahydrofuran. After stirring for 1 hour, the mixture is hydrolyzed with 1.75 ml of water, 3.5 ml of a 10% (wt/wt) sodium hydroxide solution and 7 ml of water. Filtration through celite, followed by evaporation of the solvent, yields an oily product which is used as it is in the following stage.

출처