반응 #50607

반응 방정식

6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one

1-(3-chloropropyl)-4-phenylpiperidine

Fumarate

→

7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one

수율 45.0%

용매

TBME

ethanol

methanol

TBME

반응 조건

후처리

1. 1
   기타Method D (3 h at 85° C.)

실험 절차

Method D (3 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one (example 104) and 1-(3-chloropropyl)-4-phenylpiperidine; yield 45%; fusion point 125°-126° C. (from TBME and methanol). Fumarate: method E; yield 59%; fusion point 176°-179° C. (from ethanol and TBME).

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