반응 #50604

반응 방정식

6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one

1-phenylpiperazine

Fumarate

→

7-methoxy-3,4-dimethyl-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

수율 64.0%

용매

methanol

ethanol

methanol

ethanol

반응 조건

후처리

1. 1
   기타Method A (45 h at 50° C.)

실험 절차

Method A (45 h at 50° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one (example 75) and 1-phenylpiperazine; yield 64%; fusion point 151°-152° C. (from ethanol and methanol). Fumarate (×0.5 C4H4O4): method E; yield 92%; fusion point 207°-209° C. (from ethanol and methanol).

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