반응 #50601

반응 방정식

Hydrochloride

7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one

4-[bis(4-fluorophenyl)hydroxymethyl]piperidine

methanol

→

(±)-6-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one

수율 45.0%

용매

ethanol

isopropanol

chloroform

반응 조건

후처리

1. 1
   기타Method C (5 d at 45° C.)

실험 절차

Method C (5 d at 45° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-[bis(4-fluorophenyl)hydroxymethyl]piperidine; yield 45%; fusion point 220°-221° C. (from methanol and chloroform). Hydrochloride: method G; yield 99%; fusion point 172°-174° C. (from isopropanol and ethanol).

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