반응 #50600

ord-6c21ad51386049a890bf9e863962f865

반응 방정식

COc1cc2oc(=O)ccc2cc1OCC1CO1
7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one
OC1(c2ccccc2)CCNCC1
4-hydroxy-4-phenylpiperidine
Cl
Hydrochloride
COc1cc2oc(=O)ccc2cc1OCC(O)CN1CCC(O)(c2ccccc2)CC1
(±)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one
수율 69.0%

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Method C (3 d at 40° C.)

실험 절차

Method C (3 d at 40° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-hydroxy-4-phenylpiperidine; yield 69%; fusion point 155°-157° C. (from isopropanol). Hydrochloride: method G; yield 88%; fusion point 202°-203° C. (from isopropanol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05428038uspto-grants-1995_06