반응 #50599

반응 방정식

6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one

4-phenylpiperidine

Hydrochloride

→

(±)-7-[2-hydroxy-3-(4-phenyl-1-piperidinyl)-propoxy]-6-methoxy-2H-1-benzopyran-2-one

수율 69.0%

용매

ethanol

isopropanol

ethanol

isopropanol

반응 조건

후처리

1. 1
   기타Method C (27 h at 45° C.)

실험 절차

Method C (27 h at 45° C.); starting materials; 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one (example 86) and 4-phenylpiperidine; yield 69%; fusion point 114°-115° C. (from isopropanol and ethanol). Hydrochloride: method G; yield 82%; fusion point 202°-205° C. (from isopropanol and ethanol).

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