반응 #50595

반응 방정식

Fumarate

6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one

4-phenylpiperidine

TBME

→

6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one

수율 48.0%

용매

isopropanol

acetone

반응 조건

후처리

1. 1
   기타Method B (30 h at 45° C.)

실험 절차

Method B (30 h at 45° C.); starting materials: 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one (example 72) and 4-phenylpiperidine; yield 48%; fusion point 96°-97° C. (from TBME and isopropanol). Fumarate: method E; yield 83%; fusion point 171°-173° C. (from acetone).

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